China draw resist end new medicine in corn Can wound and infect cells effectively

China draw, resist, end new medicine in corn Can wound and infect cells effectively
Kunming, November 8 of China News Service (Yang Yang Zhang GangQiang) Chinese scientist can wound the protease mutant that HIV infected cells to get one kind from the corn selectively, have offered new thinking and new strategy for researching and developing and resisting HIV medicine newly.
This is news that Ins of animal of Kunming,Academia Sinica spread from then on of today. It is Chinese drugs and severely afflicated area of AIDS to adjoin multinational Yunnan Province of Southeast Asia for a time.
News claim Ins of animal of Kunming,Academia Sinica Zheng the intersection of researcher and the intersection of discipline and group and the intersection of Chinese University of Hong Kong and discipline, Professor of PengZhu, Shao Tang make up and make and finish this subject for research forever.
Zheng researcher Tang engaged in immunology, virology and resist the intersection of HIV and medicine more than 20 years such as research forever, especially resisting HIV medicine, AIDS primate's model, virus and restraining research such as the factor from accumulating the abundant experience.
He claims, " HIV virus hides mechanisms, can hide and escape in cells the attack of host's immune system for a long time, what has already been listed has resisted HIV medicine and can not wound and infect cells and eliminate the virus selectively at present, study, have, wound HIV, infect cell and protect normal cell from, it resists HIV to be extremely important in medicine injure selectively. "
Have been cooperated for many years, has decorated and transformed a series of structure to the structural land of internal inactivation of the corn ribosomes inactivation albumen in hinterland and Hong Kong scientist, obtaining can discern and activate the peculiar corn and ribosomes inactivation and albumen mutant of HIV protease.
The research of the horizontal experiment of cell shows, this kind of mutant, to not infecting low cell toxicity, but mutant enter HIV infect behind the cell, can be discerned and cut and removed the structural land of inactivation to change into the active albumen by HIV protease in cells, thus wound HIV and infect cells selectively. The result of study still shows, because this kind of mutant can enter and infect cells with high efficiency, so it is stronger to infect the lethality of cells to HIV-1; The mutant can be able to bear HIV protease too protease of one of medicine is discerned and activated, so mutant able to bear the intersection of medicine and, infect cell, have very fine choice antipersonnel too to the intersection of HIV and protease.
Zheng Tang say these research results offer new thinking and new tactics for researching and developing specific target and infecting resisting HIV medicine to HIV newly of cells forever. "The research results have already issued and applied for the national patent in the internationally famous academic periodical " Nucleic Acids Research ". "
Zheng's revealing, 973 projects, national great science and technology of the office, Chinese the State Ministry of Science and Technology are special that this research has obtained Hong Kong subsidy for research, Chinese Academy of Sciences,etc. subsidy of project.

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